Professor of Cancer Biology
Distinguished University Professor
Director, Graduate Studies in Biology
Director, Molecular Basis of Disease
614 Petit Science Center / 404-413-5417
Cancer is a surreptitious killer that has touched all of our lives in one way or another. It is no wonder that the disease is described as the defining plague of our generation. Fortunately, decades of exhaustive research have yielded a battery of chemotherapeutic agents, the most notable of which include tubulin-binding drugs. Although these drugs can be effective to varying degrees in killing cancer cells, they are notorious for their debilitating, toxic side effects...
510 Petit Science Center / 404-413-5441
My laboratory conducts research in the areas of tumor immunology, mechanisms of tumor cell/immune cell interactions, as well as investigating the association of human adenovirus with lymphocytes and leukemia. Ongoing studies involve (1) the analysis of basic anti-tumor immunologic mechanisms and principles, (2) analysis of tumor cell-immune cell interactions and (3) investigating the possibility that human species C adenovirus can initiate acute leukemia.
Petit Science Center / 404-413-3586
432 Science Annex / 404-413-5317
The central focus of research in my laboratory is microbial biofilms, or communities of microorganisms attached to surfaces. Biofilms are widely distributed in nature, and may be beneficial or harmful to humans, depending on the microbes that inhabit them. A common feature to all of our work with biofilms is quantitative analysis of biofilm structure based on biofilms grown in flow cells and imaged by confocal microscopy...
613 Petit Science Center / 404-413-5426
To develop normally, eukaryotic organisms must carefully orchestrate the processes of differentiation, morphogenesis, and growth through spatial and temporal regulation of gene expression. The bHLH transcription factor family regulates the expression of a number of genes that modulate development, often through regulatory cascades that rely on the proper responses to sensory signals provided by the environment...
512 Petit Science Center / 404-413-5419
The goal of our research is to understand the molecular mechanism of cell abnormality, especially the conditions that are associated with many human diseases. We hope that our understanding will ultimately be converted to the development of new diagnostic and therapeutic strategies...
423 Kell / 404-413-5315
In general, this research has been directed towards the biological treatment of industrial wastes and residues generated during the production of industrial organic chemicals. This work has involved both site remediation (site clean-up) and the development of biologically based systems for the treatment of process related waste (treatment of wastes generated by current chemical processes)...
585 Petit Science Center / 404-413-5411
The major research theme of my laboratory is to understand the molecular basis of disease and help to develop new treatment strategies. We study key regulatory proteins at the molecular level by applying the techniques of bioinformatics, biochemistry and crystallography to study the structure and function of protein-ligand complexes...
618 Petit Science Center / 404-413-5407
Inflammation is a vital host response that serves as a major immunological mechanism to protect the host from pathogens, irritators and transformed / altered self-cells. Acute inflammation generally involves sequential events of local cell response and production of inflammatory mediators, activation of endothelial vasculature, transmigration of large numbers of neutrophils into tissues, and the final stage of monocyte/macrophage-mediated clearance. When the inflammatory reaction lingers and becomes chronic, local macrophage response and neutrophil infiltration are also regulated by cytokines derived from activated dendritic cells and polarized T cells. Our recent studies focus on elucidating the dynamic mechanisms that regulate leukocyte response and neutrophil transmigration at different stages of inflammation.
549 Natural Science Center / 404-413-5537
515 Science Annex / 404-413-5529
Molecular description of archaeal and eukaryotic clamp loading. Proliferating cell nuclear antigen (PCNA) is a toroidal-shaped protein (sliding clamp) that can encircle and slide along DNA...
Center for Diagnostics and Therapeutics
Associate Director, Molecular Basis of Disease
585 Natural Science Center / 404-413-6608
416 Natural Science Center / 404-413-5491
1. Transcriptional targeting by the ETS superfamily of transcription factors.ETS-family proteins, which regulate the self-renewal and differentiation of hematopoietic and neural stem cells, exemplify how transcription factors with overlapping DNA sequence preferences achieve target gene specificity...
GRA Eminent Scholar
540 Natural Science Center / 404-413-5503
787 Petit Science Center / 404-413-3591
Areas of study:
– Organic, chemoenzymatic synthesis of glycans, glycolipids, glycoproteins and lipopolisaccharides...
571 Natural Science Center / 404-413-6090
413 Natural Science Center / 404-413-5561
Unusual DNA constituents: Study and control DNA stability, recognition and dynamics.
HIV- RNA binding Zinc fingers: Design, structure and combinatorial methods to generate small RREIIB RNA binding zinc fingers that inhibit rev binding and virus production.
RNA structure: RNA quadruples as therapeutic targets. West Nile Virus-host protein interaction.
837 Langdale Hall / 404-413-5513
25 Park Place, room 744 / 404-413-5719
25 Park Place, room 742 / 404-413-6654
25 Park Place, room 751 / 404-413-5730
25 Park Place, room 743 / 404-413-5733
1. Theory: Computational Intelligence, Big Data Mining, Machine Learning, Deep Learning, and Intelligent Distributed Computing.
2. Applications: (1) Bioinformatics, Medical informatics, Health Informatics, Brain Informatics. (2) Computational Web Intelligence, Security, Intelligent Cloud Computing, Intelligent Mobile Computing. (3) Feature Selection, Decision Fusion, Hybrid Systems. (4) Green Computing, Energy Efficient Methods. (5) Optimization, Nature-Inspired Computing.
25 Park Place, room 1430 / 404-413-6434
Statistical methods in diagnostic medicine
Bootstrap and empirical likelihood methods
Non-parametric and semi-parametric regression
Discrete data analysis
Empirical process and its applications in statistics
Edgeworth expansion and saddlepoint approximation
507 Science Annex / 404-413-6037
813 Petit Science Center / 404-413-5222